Generally, no. Colorado is a no-fault state, so marital misconduct like adultery does not affect whether you can get divorced, how property is divided, or whether maintenance is awarded. The narrow exception is financial: if a cheating spouse spent significant marital money on the affair, that "dissipation" of assets can be accounted for when dividing property. While an affair may be painful, in a Colorado courtroom it usually doesn't change the legal outcome.

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Colorado, USA